GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs8072100 | 1 | rs11650372 | chr17:45721795 | C17orf57 | chr17:45401142-45518675:+ | 0.25 | 5.57 | 4.86E-8 | Very long-chain saturated fatty acid levels (fatty acid 20:0) |
| BLCA | cis | rs9894429 | 1 | rs11651264 | chr17:79576394 | TSPAN10 | chr17:79609349-79615778:+ | -0.49 | -8.84 | 3.52E-17 | Eye color traits |
| BLCA | cis | rs9894429 | 1 | rs11652797 | chr17:79574124 | TSPAN10 | chr17:79609349-79615778:+ | 0.48 | 8.69 | 1.08E-16 | Eye color traits |
| BLCA | cis | rs4803468 | 1 | rs11670668 | chr19:41920454 | B3GNT8 | chr19:41931265-41934635:- | -0.22 | -4.06 | 5.97E-5 | Height |
| BLCA | cis | rs9309473 | 1 | rs11674602 | chr2:73723185 | ALMS1P | chr2:73872046-73912692:+ | 0.35 | 5.07 | 6.22E-7 | Metabolite levels |
| BLCA | cis | rs2243480 | 1 | rs1167613 | chr7:65487439 | CCT6P1 | chr7:65216092-65228661:+ | 0.3 | 4.33 | 1.9E-5 | Diabetic kidney disease |
| BLCA | cis | rs1167827 | 1 | rs1167827 | chr7:75163169 | PMS2L3 | chr7:75137070-75157418:- | -0.42 | -8.57 | 2.58E-16 | Body mass index |
| BLCA | cis | rs1823913 | 1 | rs11681777 | chr2:192121467 | STAT4 | chr2:191894306-192038902:- | 0.14 | 3.84 | 0.000147 | Obesity-related traits |
| BLCA | cis | rs4372836 | 1 | rs11688129 | chr2:28952581 | TRMT61B | chr2:29072690-29093175:- | 0.29 | 5.1 | 5.37E-7 | Body mass index |
| BLCA | cis | rs9309473 | 1 | rs11689392 | chr2:73622026 | ALMS1P | chr2:73872046-73912692:+ | 0.36 | 5.27 | 2.26E-7 | Metabolite levels |
| BLCA | cis | rs4372836 | 1 | rs11690423 | chr2:28951537 | TRMT61B | chr2:29072690-29093175:- | 0.29 | 5.09 | 5.59E-7 | Body mass index |
| BLCA | cis | rs11088226 | 1 | rs11701091 | chr21:33920244 | TCP10L | chr21:33947152-33957845:- | -0.36 | -4.71 | 3.55E-6 | Gastritis |
| BLCA | cis | rs11088226 | 1 | rs11701627 | chr21:33927794 | TCP10L | chr21:33947152-33957845:- | -0.37 | -4.85 | 1.8E-6 | Gastritis |
| BLCA | cis | rs4253772 | 1 | rs11705483 | chr22:46630544 | PKDREJ | chr22:46651561-46659219:- | -0.45 | -4.2 | 3.35E-5 | Cholesterol, total;LDL cholesterol |
| BLCA | cis | rs10935120 | 1 | rs11706117 | chr3:134212526 | ANAPC13 | chr3:134196547-134204865:- | 0.51 | 8.12 | 6.27E-15 | Height |